Current disease targets
Coronaviruses - SARS-CoV-2, MERS-CoV
Filoviruses - Ebola
Flaviviruses - Dengue, ZIKA
(8) Discovery of Nanosota-EB1 and -EB2 as Novel Nanobody Inhibitors Against Ebola Virus Infection.
Bu, F. et al., PLOS Pathogens, 2024, In press
(7) Discovery of Nanosota-9 as anti-Omicron nanobody therapeutic candidate.
Ye, G. et al., PLOS Pathogens, 2024, [Web], [PubMed]
(6) Structure-guided in vitro evolution of nanobodies targeting new viral variants.
Ye, G. et al., PLOS Pathogens, 2024, [PDF], [Web], [PubMed]
(5) Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19.
Ye, G. et al., Journal of Virology, 2023, [PDF], [Web], [PubMed]
(4) The Development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates.
Ye, G. et al., eLife, 2021, [PDF], [Web], [PubMed]
(3) A unified mechanism for aminopeptidase N-based tumor cell motility and tumor-homing therapy.
Liu, C. et al., Journal of Biological Chemistry, 2014, [PDF], [Web], [PubMed]
(2) Structural insights into central hypertension regulation by human aminopeptidase A.
Yang, Y. et al. Journal of Biological Chemistry, 2013, [PDF], [Web], [PubMed]
(1) Structural basis for multifunctional roles of mammalian aminopeptidase N.
Chen, L. et al., PNAS, 2012, [PDF], [Web], [PubMed]
Our nanobody cancer project: